Dendropsophus microcephalus is a tree frog of the family Hylidae. They are native to Belize, Brazil, Colombia, Costa Rica, French Guiana, Guatemala, Guyana, Honduras, Mexico, Nicaragua, Panama, Suriname, Trinidad and Tobago, and Venezuela.
Females have been recorded reaching lengths of 1.2 inches long. The species undergoes color changes. During the night, its light yellow with brown or tan markings while during the day, it can be tan-yellow or light brown with brown and red markings. Males capable of breeding have yellow vocal sacs. The males gather in choruses with over a thousand individuals to call to females during mating season.